Yes!*

*With an XD driver, a few setup tips and the proper chain, our cassettes generally work well with most Shimano Derailleurs that are compatible with the cassette range. Please note new Di2 Wireless Derailleurs are not currently compatible with our cassettes.

Note: For best results, our new Helix 12 speed cassettes are specifically designed to work with Shimano™ 12 speed MTB drivetrains.

We invested a lot of hours in setting up and riding these parts so we can recommend the best setup to maximize performance with our e*thirteen 12 speed cassettes. For everything we know on the subject, jump over to our comprehensive guides.

Quick Tips:

1. You will need an XD driver on your hub.
2. Chain length is king. It is critical to follow Shimano's chain length instructions for proper performance. (These instructions are also contained in our comprehensive guides!)
3. Chain selection is important. Shimano's new 12s chains (CN-9100, etc) were designed to work specifically with Shimano's new 12s cassettes.. and may cause problems with other cassettes. Choose a chain according to the attached design graphic for best performance with your e*thirteen cassette. (These instructions are also contained in our comprehensive guides!)
4. Setup may be a little different than you're used to. Shimano™ 12s spacing is a little different than SRAM™. Our cassettes were largely designed around SRAM™ spacing, since that's all that existed when we started! This means you need to focus your attention on the largest steel sprocket on your e*thirteen cassette. Set up your shifting and limit screws as normal, then check for rubbing in the largest steel sprocket, and fine-tune to eliminate that noise.
5. B-Limit tuning. The setup markings on the Shimano™ 12s derailleurs are designed for their 51T large sprockets, and thus don't translate directly to the large sprockets on our 9-46T and 9-50T cassettes. The short answer is you probably need to adjust the b-limit screw out a bit to get the best shifting performance. (Did we mention our comprehensive guides? they've got instructions to dial this in.)