Short Answer: No, current e*thirteen TRS or Helix 12 speed cassettes are not compatible with Shimano™️ Wireless Di2 shifters and derailleurs. 

Long Answer: While current e*thirteen TRS and Helix 12-speed cassettes generally work well with many prior-generation Di2 derailleurs and Shimano 12-speed mechanical MTB rear derailleurs, they are unfortunately incompatible with the new Shimano Di2 Wireless Systems.

This incompatibility appears to be due to cog spacing differences between the first two cogs on our cassettes, which do not match the required spacing for the new wireless systems.