Answer: Yes. SRAM™️ Flattop™️ chains work well with our Helix cassettes! (But Eagle™️ chains are still our primary recommendation for best performance and longevity)
Note 1: Sram™️ "road" 12 upper derailleur pulleys are about 0.25mm thinner than their MTB counterparts. This means that either Eagle™️ and Flattop™️ chains should have no issues on SRAM™️ gravel/road derailleurs but Flattop™️ chains may bind on the wider pulley teeth of a new 12s Eagle™️ rear derailleur.
Note 2: Flattop™️ chains have rollers which are slightly larger OD than Eagle™️ chains. It is possible that these larger rollers may result in accelerated wear of drivetrain components which have not explicitly been designed for the larger OD rollers. While we have not quantified this in lab testing, we have seen varying reports of this in the field. Drivetrain wear rate is an extremely complicated topic due to the large number of variables and you can read a bit more about that here.